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Posts Tagged ‘chondroitin’

Glucosamine and Chondroitin

Glucosamine and Chondroitin


A joint health supplement is a safe and inexpensive treatment for arthritis.  Glucosamine has been used for twenty years to help with joint pain.  Nutramax is the manufacturer of CosaminDS and other glucosamine and chondroitin based joint health supplements.

The joint health supplement industry is not regulated.  That means companies can basically design and engineer their products however they see fit.  Nutramax follows pharmaceutical guidelines at their facility.  That means they produce, package, and ship their glucosamine products following the same regulations that drug companies must obey.

Nutramax has been in business since 1992.  They were the first company to market and sell glucosamine to treat osteoarthritis.  You now why they are still in business and growing?  The answer is simple.  Their products work.



A chondrocyte is a cell found within cartilage.  Chondrocytes are like small factories that produce collagen and proteoglycans – the main ingredients in the cartilaginous matrix.

Collagen is a thin, ropey protein that is the primary component of connective tissue.

Proteoglycans fill in the spaces between the collagen cells.  Glucosamine and chondroitin help strengthen the cartilaginous matrix and help control knee osteoarthritis on the cellular level.

Good News

Good News

Chondroitin Sulphate reduces the volume of cartilage loss.  This is what was proven by a group of Canadian researchers. They published a clinical trial that shows for the first time the disease modifying effects of chondroitin sulfate.  The study looked at quantifying changes in cartilage, over time, by utilizing MRI results.

Patients with knee osteoarthritis were divided into two groups.  One group took chondroitin sulfate,  the control group took a placebo.  After six months MRI results showed that the group of patients taking chondroitin sulfate showed a significant decrease in the loss of articular cartilage.

The lead researcher, Professor Jean-Pierre Pelletier said, “Chondroitin Sulfate is a safe drug with an overall positive effect on OA.”

This study was conducted at the Osteoarthritis Research Unit at the University of Montreal Hospital Research Centre, and published in the Annals of Rheumatic Diseases.

Avoca ASU

Avoca ASU

Avoca ASU from Nutramax is a joint health supplement that contains non-shellfish glucosamine, NMX1000 avocado/soybean unsaponifiables (ASU), and methylsulfonylmethane (MSM).  It also has decaffeinated green tea for antioxidant health benefits.  All ingredients are from non-animal origin.

So vegetarians and those allergic to shellfish now have a new treatment option for their knee osteoarthritis.  If you couldn’t take Cosamin DS – try Avoca ASU.

Cosamin ASU

Cosamin ASU

CosaminDS has been the premium joint health supplement on the market for over ten years.  Nutramax has discovered a method of making their original product more effective.  Cosamin ASU is maximum strength glucosamine and chondroitin.

This new formula from Nutramax is trademarked and shown in cell studies to be better than the combination of glucosamine and chondroitin sulfate at inhibiting several agents involved in cartilage breakdown.

If Cosamin DS helped with your knee osteoarthritis then this product can take your pain relief to an entire new level.

Cosamin DS

Cosamin DS

Cosamin DS is the only brand of glucosamine and chondroitin proven effective in published U.S. studies.  The studies show that joint pain is reduced.

Cosamin DS, designed and manufactured by Nutramax Labs, contains the full clinical strength of glucosamine and chondroitin.  Nutramax Labs manufacture this joint health supplement as if it were a pharmaceutical – meeting rigorous production and safety protocols.

Thousands of patients have successfully used Cosamin DS to treat their osteoarthritis of the knee.



This blog post is a continuation of a series of articles from the American Academy of Orthopedic Surgeons’ (AAOS) Full Guideline for the Treatment of Osteoarthritis.

Recommendation 12 – The AAOS recommends that glucosamine and/or chondroitin sulfate or hydrochloride not be prescribed for patients with symptomatic osteoarthritis of the knee.

This recommendation was based on a report from the Agency for Healthcare Research and Quality.  The report was based on one random controlled trial and six systematic reviews on the use of chondroitin sulfate, and/or glucosamine, or hydrochloride among patients with osteoarthritis of the knee.

The random controlled trial found that glucosamine and/or chondroitin did not have any clinical benefit, though five of the six systematic reviews concluded that glucosamine and/or chondroitin are superior to placebo.

Since the Random Controlled Trial is stronger science than the systematic reviews, the AAOS based their decision on the one study.

This is a continuation of our series on the Osteoarthritis Research Society International (OARSI) recommendations for the management of hip and knee osteoarthritis published in the Journal of Osteoarthritis and Cartilage.

glucosamine and chondroitin

Recommendation XVIII

Glucosamine and Chondroitin sulphate may be effective in providing symptomatic pain relief in patients with knee osteoarthritis.

Analysis of eight randomized controlled trials involving 755 patients reported moderate pain reduction.  However with so many products on the market with varying purity levels of glucosamine and chondroitin there is significant controversy as to the efficacy of this treatment option for knee osteoarthritis.

No adverse effects are reported from long-term use of glucosamine and chondroitin.  However if no response is apparent within 6 months treatment should be discontinued.

The research team gave this osteoarthritis treatment option a Strength of Recommendation score of 63%.

W. Zhang Ph.D., Moskowitz M.D., et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis and Cartilage. (2008) 16, 137-162.

OA Effects Your Pets Too

OA Effects Your Pets Too

Aging cats and dogs are effected by osteoarthritis just like us.

Osteoarthritis (OA) is usually caused by wear and tear in older dogs.  Canines are prone to hip and knee arthritis.  And it usually shows itself as pain, swelling and stiffness.  Treatments for OA in dogs are similar to humans – decrease their weight, provide gentle exercise (your dog will tell you how much he/she can handle) and regulate their diet.

Cats do not present with the same symptoms as dogs.  They are also better at hiding their pain.  Seeing that cats sleep 13 to 16 hours per day you really have to pay attention to see if they are hurting.  A good measure of their joint health is to see if they jump as high or as often as they usually do.

Glucosamine is recommended to stimulate joint function and relieve pain associated with osteoarthritis in cats, dogs, horses, and humans!  Glucosamine is an important component of cartilage and is usually used in conjunction with chondroitin.

Nutramax, the manufacturer of CosaminDS, a glucosamine and chondroitin osteoarthritis supplement has a veterinarian division.  The company actually started as a manufacturer of a veterinarian joint supplements called Cosequin.  It wasn’t until a reporter for the New York Times wrote a story about how great the supplement worked for her dog that the products for human consumption took off!


Glucosamine is naturally occurring in cartilage. Glucosamine’s primary function is to lubricate joints and help rebuild cartilage.  Glucosamine  does not have serious side effects and is safe for the treatment of osteoarthritis.   Glucosamine is made from shellfish so those allergic should take precaution.

There are non-shellfish glucosamine products available.

Chondroitin is regularly used in conjunction with Glucosamine.   Chondroitin, like glucosamine is found in cartilage.  Chondroitin improves elasticity in cartilage and helps protect the  joint from injury. Chondroitin has no serious side effect.  Though sometimes mild gastrointestinal issues can occur.