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Archive for August 26th, 2010



This blog post is a continuation of a series of articles from the American Academy of Orthopedic Surgeons’ (AAOS) Full Guideline for the Treatment of Osteoarthritis.

Recommendation 12 – The AAOS recommends that glucosamine and/or chondroitin sulfate or hydrochloride not be prescribed for patients with symptomatic osteoarthritis of the knee.

This recommendation was based on a report from the Agency for Healthcare Research and Quality.  The report was based on one random controlled trial and six systematic reviews on the use of chondroitin sulfate, and/or glucosamine, or hydrochloride among patients with osteoarthritis of the knee.

The random controlled trial found that glucosamine and/or chondroitin did not have any clinical benefit, though five of the six systematic reviews concluded that glucosamine and/or chondroitin are superior to placebo.

Since the Random Controlled Trial is stronger science than the systematic reviews, the AAOS based their decision on the one study.