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Posts Tagged ‘nonsteroidal anti-inflammatory drug’



Non-steroidal anti inflammatory drugs (NSAIDs) relieve the pain associated with knee osteoarthritis on a chemical level.

Enzymes called Cox-1 and Cox-2 are a contributing factor in the creation of prostaglandins.  Prostaglandins are responsible for swelling and the sensation of pain.  NSAID’s block Cox enzymes, so your body does not produce as many prostaglandins.

So NSAID’s reduce pain and swelling by blocking Cox-1 and Cox-2 enzymes, thus your body doesn’t produce as many prostaglandins, and pain and swelling is reduced.



NSAIDs are commonly prescribed and recommended to treat the pain associated with osteoarthritis of the knee.  This series of posts is about the side effects associated with nonsteroidal anti-inflammatory drugs.  Some of the problems that these medications cause are very serious and can adversely effect your health much worse than the pain in your knee caused by OA.

  • Liver Failure
  • Kidney Failure
  • Heart Attack
  • Stroke
  • Death

NSAID use has been linked to all of the above conditions.  It is important you talk to your doctor and know all of the risks associated with any medication you take.  With NSAIDs, know all of the precautions you must take to safely treat your knee pain.

Think about a conservative treatment option for your knee OA.  Nobody has ever died from wearing a knee brace.



Knee osteoarthritis is often treated with nonsteroidal anti-inflammatory drugs.  NSAIDs can have some potentially serious side effects.  Tinnitus is one of those possible side effects.

Tinnitus – this is not a disease but an aural condition.  It is characterized by noises in your head when everything is quiet.  Tinnitus is usually worse at night or when in very quiet places.  The noises can occur in one or both ears and can sound like buzzing whistling, ringing, or hissing.



Allergic Reactions are a known and well-documented side effect associated with NSAIDs used to treat OA of the knee.  Nonsteroidal anti-inflammatory drugs are often recommended and prescribed to reduce the pain and swelling associated with knee osteoarthritis.  Symptoms of an allergic reaction may include:

  • Rash
  • Itching
  • Swelling
  • Dizziness
  • Shortness of Breath

Your physician should be contacted immediately if you notice any of the following symptoms.  If you have trouble breathing call 911.



Nonsteroidal Anti-inflammatory Drugs are often used to treat osteoarthritis of the knee.  However these medications are associated with a host of side effects.  This series of blog posts examines these side effects.

NSAID use can lead to fatigue and drowsiness.  Fatigue is different than drowsiness.  Drowsiness is the need to sleep.  Fatigue is a lack of energy and/or motivation.  This encompasses both physical and mental conditions.  It should be left up to a physician to distinguish between the two.


                      Upset Stomach

NSAID’s are commonly used to treat knee osteoarthritis.  However these medications have side effects.  Gastrointestinal problems rank as a leading problem associated with the use of nonsteroidal anti-inflammatory drugs.

Symptoms can include but are mot limited to:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Decreased Appetite
  • Heartburn
  • Ulcers
  • Stomach Ache

Notify your doctor if you experience any of these side effects.  Also ask about knee braces to treat your osteoarthritis of the knee.  Knee braces don’t cause ulcers.


November 6, 2010


Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs that relieve pain and reduce fever.  In higher doses these drugs can have anti-inflammatory effects.

The most common members of this drug group are ibuprofen, aspirin, and naproxen.

NSAIDs are often times indicated for treating chronic and acute conditions that present with inflammation and pain.  They are commonly prescribed and recommended as a treatment option for knee osteoarthritis.

This series of blog posts is about the side effects associated with nonsteroidal anti-inflammatory drugs.