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OARSI – Recommendation XIX: Glucosamine May Have Structure-Modifying Effects in Patients with Symptomatic Knee OA

July 31, 2010

This is a continuation of our series on the Osteoarthritis Research Society International (OARSI) recommendations for the management of hip and knee osteoarthritis published in the Journal of Osteoarthritis and Cartilage.

glucosamine and chondrotin

Recommendation XIX

In patients with symptomatic knee OA glucosamine sulphate and chondrotin sulphate may have structure-modifying effects.

Two randomized controlled trials involving 414 patients reported evidence that 1500mg of glucosamine sulphate taken on a daily basis may have structure-modifying effects in patients with knee OA.  This means cartilage may be rebuilt.

The research team gave this osteoarthritis treatment option a Strength of Recommendation score of 41%.

W. Zhang Ph.D., Moskowitz M.D., et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis and Cartilage. (2008) 16, 137-162.




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