NSAID Side Effects – Edema
Observable swelling from fluid retention in the tissues of your body is called edema. Edema is a possible side effect from using nonsteroidal anti-inflammatory drugs to treat the osteoarthritis in your knee. The swelling is most common in the feet and ankles.
Swollen ankles can also be a symptom of heart, kidney, and respiratory problems. Edema can be the sign of a serious medical condition. Since NSAID use can also result in serious heart, kidney, and respiratory problems, consult your physician immediately is your ankles swell unexpectedly.