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Doxycycline – No Help For Osteoarthritis

August 8, 2011
Back to the Drawing Board

Back to the Drawing Board

Doxycycline is an antibiotic and is being considered as a disease modifying osteoarthritis drug (DMOAD).  It is used to treat infections.  Doxycycline has been found to inhibit the enzyme metalloproteinase.  This enzyme helps destroy cartilage.  Some research has suggested that doxycycline helps slow OA’s progression.

A recent Dutch study looked at how doxycycline effects pain and function in patient with OA.  Unfortunately the study showed that doxycycline is not effective in reducing symptomatic pain, stiffness, or function in knee OA.  Also it was associated with negative side effects.

So it’s back to the drawing board for synthetic metalloproteinase inhibitors.



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