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Archive for August 4th, 2011

Future OA Treatments

Future OA Treatments

Are DMOADs the future?  Many physicians and researchers believe that Disease Modifying Osteoarthritis Drugs are exactly that.

One of the arrows missing from the physician’s quiver of treatment options for osteoarthritis is disease modification.  However, to date the pharmaceutical industry has failed to bring effective and safe disease modifying OA treatments to the market.  Clinical trials are underway researching compounds that inhibit matrix-metalloproteinases (MMPs), bisphosphonates, cytokine blockers, calcitonin, inhibitors of inducible nitric oxide synthase (iNOS), doxycycline, glucosamine, and diacereine.

Early results are positive, showing that some interventions have been shown to slow the progression of osteoarthritis, and several new classes of molecules have been discovered that inhibit one or more “OA pathophysiological processes”.

We will let you know as more information on any of these treatment options become available.