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Archive for August 28th, 2010

Cox II Inhibitor

Cox II Inhibitor

This blog post is one in a series of articles about the American Academy of Orthopedic Surgeons’ (AAOS) Full Guideline for Treatment of Knee Osteoarthritis.

Recommendation 14 – The AAOS suggests that patients with symptomatic osteoarthritis of the knee and an increased gastrointestinal risk (patients older than 60), multiple medical conditions, peptic ulcer disease, GI bleeding, concurrent corticosteroid and/or concomitant (at the same time) use of anticoagulants receive one of the following for pain relief:

  • Acetaminophen
  • Topical non steroidal anti inflammatory drugs (NSAIDs)
  • nonselective oral NSAIDs plus gastro-protective agent
  • Cyclooxygenase (Cox II inhibitors)

The AAOS reports that each of these treatment options for osteoarthritis of the knee has a reduced risk of GI complications when compared to the isolated use of oral NSAIDs.  The evidence does not say that one treatment options is more advantageous than another.