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Archive for July 29th, 2010

This is a continuation of our series on the Osteoarthritis Research Society International (OARSI) recommendations for the management of hip and knee osteoarthritis published in the Journal of Osteoarthritis and Cartilage.

Hyaluronate Injection

Intra-articular injections of hyaluronate may be useful in patients with hip and knee osteoarthritis.

Hyaluronate is characterized by delayed onset, but it works longer for symptomatic pain relief when compared to injections of corticosteroids.  Injections of hyaluronate in the knee supplement existing synovial fluid with gel-like substances.

A comprehensive industry-sponsored review of 40 placebo-controlled trials involving viscosupplementation found improvements in pain.  No major safety issues were detected but adverse events such as transient pain at the injection site were reported.

The research team gave this osteoarthritis treatment option a Strength of Recommendation score of 64%.

W. Zhang Ph.D., Moskowitz M.D., et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis and Cartilage. (2008) 16, 137-162.